Titre : |
Studies in Humans and Mice Implicate Neurocan in the Etiology of Mania |
Type de document : |
texte imprimé |
Auteurs : |
Xavier Miro ; Sandra Meier ; Maie Luise Dreisow |
Année de publication : |
2012 |
Article en page(s) : |
982-990 p. |
Note générale : |
Reçu le 24 Septembre 2012 |
Langues : |
Anglais (eng) |
Catégories : |
[Thesaurus n°1] lithium [Thesaurus n°1] souris
|
Mots-clés : |
état maniaque |
Résumé : |
Genome-wide association has been reported between the NCAN gene and bipolar disorder. The aims of this study were to characterize the clinical symptomatology most strongly influenced by NCAN and to explore the behavioral phenotype of Ncan knockout (Ncan-/-) mice. NCAN preferentially affected mania symptoms in humans. Ncan-/- mice showed behavioral abnormalities that were strikingly similar to those of the human mania phenotype and may thus serve as a valid mouse model. |
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