Auteur LEBOYER Marion
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Documents disponibles écrits par cet auteur (3)
Ajouter le résultat dans votre panier Faire une suggestion Affiner la recherche Interroger des sources externesCSMD1 rs10503253 increases schizophrenia risk in a Tunisian population-group [rs10503253 du gène CSMD1 augmente le risque de la schizophrénie en Tunisie] / MIHOUB Ons in L'encéphale, n°4 (Août 2024 Vol.50)
Titre : CSMD1 rs10503253 increases schizophrenia risk in a Tunisian population-group [rs10503253 du gène CSMD1 augmente le risque de la schizophrénie en Tunisie] Auteurs : MIHOUB Ons, Auteur ; BEN CHAABEN Arij, Auteur ; BOUKOUACI Wahid, Auteur ; LAJNEF Mohamed, Auteur ; AYARI Fayza, Auteur ; EL KEFI Hamdi, Auteur ; BEN AMMAR Hanen, Auteur ; ABAZZA Hajer, Auteur ; EL HECHMI Zouhair, Auteur ; GUEMIRA Fathi, Auteur ; LEBOYER Marion, Auteur ; TAMOUZA Ryad, Auteur ; KHARRAT Maher, Auteur Année de publication : 2024 Article en page(s) : 380-385 Note générale : 33 réf. bibliogr./ 5 tabl. Langues : Anglais (eng) Mots-clés : TUNISIE SCHIZOPHRENIE GENETIQUE Résumé : Schizophrenia is a complex and chronic neuropsychiatric disorder. Recent genome-wide association studies have identified several at risk genetic variants, including two single nucleotide polymorphisms, namely the rs10503253 and the rs1270942 respectively located in the CSMD1 and the CFB loci. The present case-control study was designed to assess potential associations between the two variants and the risk of developing schizophrenia and disease severity. Further we demonstrate the relationship between these variants and clinical characteristics in a population-group from Tunisia. Patients and methods : In total, 216 patients diagnosed with schizophrenia along with176 healthy controls were included in this case–control study. The molecular analysis of the two polymorphisms was performed using tetra the Primer Amplification Refractory Mutation System–Polymerase Chain method. The statistical analysis was done using Compare V2.1 software, and correlations between genetic results and clinical characteristics were examined by Kruskal-Wallis testing. Results : The frequency of the rs10503253A allele was found significantly higher among patients with schizophrenia as compared to healthy controls and associated with high negative PANSS scores. While no association was found concerning the implication of the rs1270942 variant in schizophrenia risk, a positive correlation with high positive PANSS scores was further observed. Conclusion : The present finding confirms the previously reported association between the Cub and Sushi multiple Domain 1 rs10503253A allele and the risk to develop schizophrenia and identified the rs1270942 variant as a potential disease risk modifier. Such observations may be important for the definition of the susceptible immunogenetic background in North African individuals at risk to develop mental disorders. [résumé d'auteur] En ligne : https://www.em-premium.com/article/1681093 Permalink : https://ch-poitiers.fr/opac_css/index.php?lvl=notice_display&id=121542
in L'encéphale > n°4 (Août 2024 Vol.50) . - 380-385[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité P0000498 ENC/04-24 Périodique CDMA Documentaire Disponible
Titre : Association between genetic variants of TLR2 , TLR4 , TLR9 and schizophrenia [Association entre les variants génétiques des TLR2 , TLR4 , TLR9 et la schizophrénie] Auteurs : AYARI F, Auteur ; BEN CHAABEN A, Auteur ; ABAZA H, Auteur ; MIHOUB O, Auteur ; OUNI N, Auteur ; BOUKOUACI Wahid, Auteur ; KHARRAT Maher, Auteur ; LEBOYER Marion, Auteur ; GUEMIRA F, Auteur ; TAMOUZA R, Auteur ; MANKAI Amani, Auteur Année de publication : 2024 Article en page(s) : 178-184 Note générale : 47 réf. bibliogr./Tabl./Fig. Langues : Anglais (eng) Mots-clés : TUNISIE LIMITE SCHIZOPHRENIE GENETIQUE GENOTYPE ETIOLOGIE Résumé : Background and study aim : Schizophrenia (SZ) is a multifactorial disorder involving complex interactions between genetic and environmental factors, where immune dysfunction plays a key etiopathogenic role. In order to explore the control of innate immune responses in SZ, we aimed to investigate the potential association between twelve TLR2, TLR4 and TLR9 variants (TLR2: rs4696480T > A, rs3804099T > C, rs3804100T > C; TLR4: rs1927914G > A, rs10759932T > C, rs4986790A > G, rs4986791T > C, rs11536889G > C, rs11536891T > C; TLR9: rs187084A > G, rs352139T > C and rs352140C > T) and SZ susceptibility in a Tunisian population. Patients and methods : This study included 150 patients and 201 healthy controls with no history of psychiatric illness. Genotyping was done using a TaqMan SNP genotyping assay. We also assessed a haplotype analysis for TLR2, TLR4 and TLR9 variants with SZ using Haploview 4.2 Software. Results : We found that the AA genotype of the TLR2 rs4696480T > A variant was significantly associated with an increased risk of SZ (46% vs. 31%, P = 4.7 × 10−3, OR = 1.87 and 95% CI [1.18–2.97]). The frequency of the TA genotype was significantly higher in the control group than in SZ patients (27% vs. 43%, P = 2.1 × 10−3) and may be associated with protection against SZ (OR = 0.49 and 95% CI [0.30–0.80]). Whereas, the TLR9 rs187084-GG genotype was higher in the control group compared to patients (16% vs. 5%, P = 1.6 × 10−3) and would present protection against SZ (OR = 0.28, CI = [0.10–0.68]). The ACT haplotype of the TLR2 and the ACC haplotype of the TLR9 gene were identified as a risk haplotypes for SZ (P = 0.04, OR = 9.30, 95% CI = [1.11–77.71]; P = 3 × 10−4, OR = 6.05, 95% CI = [2.29–15.98], respectively). Conclusion : The results indicate that TLR2 and TLR9 genetic diversity may play a role in genetic vulnerability to SZ. However, including more patients and evaluation of TLR2 and TLR9 expression are recommended. [Résumé d'auteur] En ligne : https://www.em-premium.com/article/1656798 Permalink : https://ch-poitiers.fr/opac_css/index.php?lvl=notice_display&id=121509
in L'encéphale > n°2 (Avril 2024 Vol. 50) . - 178-184[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité P0000455 ENC/24-02 Périodique CDMA Documentaire Disponible
Titre : Retinal electrophysiological markers for precision medicine in psychiatry [Editorial] [Marqueurs électrophysiologiques rétiniens pour la médecine de précision en psychiatrie] Auteurs : SCHWITZER Thomas, Auteur ; LEBOYER Marion, Auteur ; SCHWAN Raymund, Auteur Année de publication : 2023 Article en page(s) : 107-108 Note générale : 5 réf. bibliogr. Langues : Anglais (eng) Mots-clés : OEIL MARQUEUR BIOLOGIQUE PATHOLOGIE PSYCHIATRIQUE NEURONE En ligne : https://www.em-premium.com/article/1579994 Format de la ressource électronique : https://www.em-premium.com/article/1579994 Permalink : https://ch-poitiers.fr/opac_css/index.php?lvl=notice_display&id=121227
in L'encéphale > n°2 (Avril 2023 Vol. 49) . - 107-108[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité P0000410 ENC/23-02 Périodique CDMA Documentaire Disponible
