Genetic Variation in KCNH2 Associated With Expression in the Brain of a Unique hERG Isoform Modulates Treatment Response in Patients With Schizophrenia / José A. Apud in The American Journal of Psychiatry, Vol. 169 - N°7-Juil (2012)

Public Aucun avis sur cette notice. [article]  inThe American Journal of Psychiatry > Vol. 169 - N°7-Juil (2012) . - p. 725-734 Titre : Genetic Variation in KCNH2 Associated With Expression in the Brain of a Unique hERG Isoform Modulates Treatment Response in Patients With Schizophrenia Type de document : texte imprimé Auteurs : José A. Apud, Auteur ; Fengyu Zhang ; Heather Decot Année de publication : 2012 Article en page(s) : p. 725-734 Langues : Anglais (eng) Résumé : Antidopaminergic drugs bind to hERG1 potassium channels encoded by the gene KCNH2, which accounts for the side effect of QT interval prolongation. KCNH2 has also been associated with schizophrenia risk, and risk alleles predict increased expression of a brain-selective isoform, KCNH2 3.1, that has unique physiological properties. Permalink : https://ch-poitiers.fr/opac_css/index.php?lvl=notice_display&id=75136 [article]

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